3 research outputs found

    A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

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    Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providing insight into human mutations in this region
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